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It was the Celebrex that gave me the most relief Conclusions: In the treatment of osteoarthritis, celecoxib is as effective as the nonspecific NSAIDs naproxen and diclofenac, but has significantly fewer serious upper gastrointestinal events. This makes it the best choice in patients who are at risk of GI bleeding. If you take a few times a month, Voltaren is better. Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol). 9k views Reviewed >2 years ago Thank Dr. However, because of the risk of heart attack, you should limit the amount you take. Celebrex is an NSAID, which has selective inhibition of the COX 2. However, celecoxib appears to have a superior safety and tolerability profile. Voltaren is more effective treatment but Celebrex is better is safer if you take every day Reply Guest over a year ago. 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