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RA is an autoimmune condition that’s caused by your immune system mistakenly attacking the lining of your joints. Celebrex (celecoxib) relieves pain and inflammation by blocking COX-2 enzymes, which are responsible for the synthesis of prostaglandins (prostaglandins are released during inflammation and elevate body temperature and make nerve endings more sensitive to pain transmission. These medications may help alleviate pain and/or inflammation. Aleve ( naproxen) and Celebrex ( celecoxib) are nonsteroidal anti-inflammatory drugs ( NSAIDs) used to treat arthritis, pain, menstrual cramps, and fever. Brand names include Naprosyn, Aleve, Anaprox, and Midol. Medications that control pain are known as analgesics, and they are available in OTC and prescription forms Primary Menu Menu. Celebrex is a brand (trade) name of the drug celecoxib. Drugs that nourish the heart muscle and improve its metabolism may also be prescribed. 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